One trial points to Radiesse, with a catch about what it measured. This page covers what that trial found and how far the finding reaches.
What the trial found
NEJM Clinician reports that for correction of nasolabial folds, calcium hydroxylapatite provided greater long-term satisfaction.
The comparison was against hyaluronic acid fillers, and calcium hydroxylapatite is the material in Radiesse.
How the trial was run
NEJM Clinician describes a multicenter, randomized comparison trial from Europe funded by the maker of Radiesse, in which 205 patients received Radiesse or one of three hyaluronic acid (HA) fillers for nasolabial fold correction.
Two details limit the reach of the result. The finding is about satisfaction rather than a month count, and it covers nasolabial folds, not every area of the face.
Safety and product choice
Whatever lasts longer, safety belongs in the decision. A meta-analysis of adverse events reported from hyaluronic acid filler injections and a systematic literature review of safety and complications with dermal fillers give the wider evidence.
The FDA's dos and don'ts for dermal fillers is a short checklist. Nebraska Medicine's article on which type of dermal filler is best helps match product to area.
Questions for your injector
Ask your provider which product fits the area you want treated and why. Ask what result they expect over time.
Why the nasolabial result stops at the nasolabial folds
The answer changes with the treatment area. A result about nasolabial folds should be rechecked before you apply it to another part of the face.